Clinicopathologic and endoscopic characteristics of ten patients with gastric hamartomatous inverted polyp: a single center case series.

BACKGROUND: Gastric hamartomatous inverted polyps (GHIPs) are not well characterized and remain diagnostically challenging due to rarity. Therefore, this study aims to investigate the clinicopathologic and endoscopic characteristics of patients with GHIP. METHODS: We retrospectively reviewed clinicopathologic and endoscopic features of ten patients with GHIP who were admitted to Beijing Friendship Hospital from March 2013 to July 2022. All patients were treated successfully by endoscopic resection. RESULTS: GHIPs were usually asymptomatic and found incidentally during gastroscopic examination. They may be sessile or pedunculated, with diffuse or local surface redness or erosion. On endoscopic ultrasonography, the sessile submucosal tumor-type GHIP demonstrated a heterogeneous lesion with cystic areas in the third layer of the gastric wall. Histologically, GHIPs were characterized by a submucosal inverted proliferation of cystically dilated hyperplastic gastric glands accompanied by a branching proliferation of smooth muscle bundles. Inflammatory cells infiltration was observed in the stroma, whereas only one patient was complicated with glandular low-grade dysplasia. Assessment of the surrounding mucosa demonstrated that six patients (60%) had atrophic gastritis or Helicobacter pylori-associated gastritis, and four patients (40%) had non-specific gastritis. Endoscopic resection was safe and effective. CONCLUSIONS: GHIPs often arise from the background of abnormal mucosa, such as atrophic or H.pylori-associated gastritis. We make the hypothesis that acquired inflammation might lead to the development of GHIPs. We recommend to make a full assessment of the background mucosa and H. pylori infection status for evaluation of underlying gastric mucosal abnormalities, which may be the preneoplastic condition of the stomach.

Efficacy and safety of Shenbai Granules for recurrent colorectal adenoma: A multicenter randomized controlled trial.

BACKGROUND: Colorectal adenoma is benign glandular tumor of colon, the precursor of colorectal cancer. But no pharmaceutical medication is currently available to treat and prevent adenomas. PURPOSE: To evaluate efficacy of Shenbai Granules, an herbal medicine formula, in reducing the recurrence of adenomas. STUDY DESIGN: This multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted by eight hospitals in China. METHODS: Patients who had received complete polypectomy and were diagnosed with adenomas within the recent 6 months were randomly assigned (1:1) to receive either Shenbai granules or placebo twice a day for 6 months. An annual colonoscopy was performed during the 2-year follow-up period. The primary outcome was the proportion of patients with at least one adenoma detected in the modified intention-to-treat (mITT) population during follow-up for 2 years. The secondary outcomes were the proportion of patients with sessile serrated lesions and other specified polypoid lesions. The data were analyzed using logistic regression. RESULTS: Among 400 randomized patients, 336 were included in the mITT population. We found significant differences between treatment and placebo groups in the proportion of patients with at least one recurrent adenoma (42.5 % vs. 58.6 %; OR, 0.47; 95 % CI, 0.29-0.74; p = 0.001) and sessile serrated lesion (1.8 % vs. 8.3 %; OR, 0.20; 95 % CI, 0.06-0.72; p = 0.01). There was no significant difference in the proportion of patients developing polypoid lesions (70.7 % vs. 77.5 %; OR, 1.43; 95 % CI, 0.88-2.34; p = 0.15) or high-risk adenomas (9.0 % vs. 13.6 %; OR, 0.63; 95 % CI, 0.32-1.25; p = 0.18). CONCLUSION: Shenbai Granules significantly reduced the recurrence of adenomas, indicating that they could be an effective option for adenomas. Future studies should investigate its effects in larger patient populations and explore its mechanism of action to provide more comprehensive evidence for the use of Shenbai Granules in adenoma treatment.

Carvedilol Plus NUC for Patients With HBV-Compensated Cirrhosis Under Virological Suppression: A Randomized Open-Label Trial.

INTRODUCTION: Portal hypertension progression can be relieved after controlling the etiology of liver cirrhosis. Whether beta-blockers could additionally enhance the effects during treatment, particularly for small esophageal varices (EV), was unclear. This study aims to assess the efficacy of add-on carvedilol to delay EV progression during anti-hepatitis B virus (HBV) treatment in HBV-related cirrhosis. METHODS: This randomized controlled trial enrolled patients with virologically suppressed HBV-compensated cirrhosis and small/medium EV. The participants were randomly assigned to receive nucleos(t)ide analog (NUC) or carvedilol 12.5 mg plus NUC (1:1 allocation ratio). The primary end point was the progression rate of EV at 2 years of follow-up. RESULTS: A total of 238 patients (small EV, 77.3%) were randomized into 119 NUC and 119 carvedilol plus NUC (carvedilol [CARV] combination group). Among them, 205 patients (86.1%) completed paired endoscopies. EV progression rate was 15.5% (16/103) in the NUC group and 12.7% (13/102) in the CARV combination group (relative risk = 0.79, 95% confidence interval 0.36-1.75, P = 0.567). Subgroup analysis on medium EV showed the CARV combination group had a more favorable effect in promoting EV regression (43.5% vs 13.1%, P = 0.022) than NUC alone, but not in small cases ( P = 0.534). The incidence of liver-related events (decompensation, hepatocellular carcinoma, or death/liver transplantation) within 2 years was similar between the 2 groups (11.2% vs 10.4%, P = 0.881). DISCUSSION: The overall results did not show statistically significant differences between the added carvedilol strategy and NUC monotherapy in preventing EV progression in patients with virologically suppressed HBV-compensated cirrhosis. However, the carvedilol-added approach might offer improved outcomes specifically for patients with medium EV (NCT03736265).

Highly Antibacterial and Self-Healing Janus Fabric for Effective Body Moisture/Thermal Management and Durable Waterproof.

Despite the development of many functional fabrics, they are unable to meet practical needs due to their monolithic functions and low durability. Therefore, a multifunctional waterborne polyurethane nanodroplet containing disulfide bonds (WSPU) was synthesized using a simple and environmentally friendly approach. The functional WSPU nanodroplet coating endowed fabrics with a variety of properties, including exceptional hydrophobicity, antibacterial properties, self-healing at room temperature, directional transport, etc. The functionalized fabric demonstrated durable mechanical and chemical stabilities due to the combined effects of disulfide bond reconstruction and hydrophobic chain migration. It exhibited the ability to regain its hydrophobic properties at room temperature after 50 friction cycles were performed without requiring external stimulation. Furthermore, the fabric maintained a water contact angle above 140°, even after being subjected to washing, boiling, and immersion in acid and alkali solutions. In addition, as a result of the fabric's Janus-like wettability, it performed various functions in accordance with varying weather conditions, in terms of wearing comfort and breathability. In hot weather or during exercise, the Janus fabric with the hydrophilic side facing outward enhances the process of sweat-directed perspiration, resulting in a notable cooling effect. On rainy days, the Janus fabric, when positioned with the hydrophobic side facing outward, exhibited excellent waterproof performance. This study presents an opportunity to explore the development of multifunctional fabrics through the combined effects of several functions.

Bioinspired Flexible Wearable Sensor with High Self-Cleaning and Antibacterial Performance for Human Motion Sensing.

Flexible wearable strain sensors have shown great potential in monitoring human motion, due to their ability to flexibly fit to multiple surfaces, which can realize the monitoring of human motions and external stimulation. However, the utilization of the sensor in extreme conditions such as low or high temperatures still poses a risk of signal output distortion. Moreover, the continuous usage of the sensor may result in extensive bacterial growth at the interface between the sensor and the skin, posing a threat to human health. Herein, a hydrophobic flexible antibacterial strain sensor (CGP) based on carbon black-PDMS was prepared, inspired by the superhydrophobic surface of a lotus leaf. The CGP sensor demonstrates exceptional sensitivity, with a gauge factor (GF) of 0.467 in the strain range of 0-15% and a fast response time (65.4 ms, 5% strain). Additionally, it exhibits a high conductivity of 1.2 mS cm-1 at -20 °C and 2.0 mS cm-1 at 100 °C, indicating its ability to function effectively even in extreme temperatures. The static water contact angle of CGP measures 121.7°, and self-cleaning experiments have confirmed its excellent self-cleaning performance. Furthermore, the CGP displays distinct response characteristics to movements of human fingers, wrists, and knees, making it an ideal choice for monitoring various joints in the human body. In terms of antibacterial properties, CGP has demonstrated an antibacterial rate of over 99% against E. coli and S. aureus. Possessing high sensitivity, superior electrical conductivity in harsh environments, and super antibacterial capabilities, CGP holds significant potential for applications in human motion monitoring and other fields.

Spatiotemporal variation of cold requirements for leaf coloration and its environmental cues over the northern deciduous broadleaved forests.

Evaluating the interactions between cold requirements for leaf coloration and environmental cues is crucial for understanding the mechanisms of leaf senescence and accurately predicting autumn phenology. Based on remote sensing-derived and ground-observed leaf coloration dates for deciduous broadleaf forests during 1981-2014, we determined location-specific cold requirements for autumn leaf coloration and assessed their spatiotemporal changes. Then, we revealed the major environmental cues of cold requirements and their spatial differentiation. Results show that cold requirements have nonsignificant trends during the past decades at 57.9% of pixels. The interannual variation of cold requirements was mainly influenced by growing-season accumulated temperature (GDDgs) at 35.8% of pixels and accumulated growing season index (AGSI) at 23.2% of pixels, but less affected by leaf unfolding and low precipitation index (LPI). The increase in GDDgs or AGSI may decrease cold requirements, and vice versa. The spatial differentiations of the effects of GDDgs and AGSI depend highly on local summer temperature among climatic classifications with similar humidity conditions. Specifically, the effects of GDDgs on cold requirements concentrated in humid regions with warmer summers, while that of AGSI mainly occurred in humid and winter dry regions with cooler summers. Higher summer temperatures would strengthen the effects of GDDgs and reduce the effects of AGSI on cold requirements. These findings deepen the understanding of the influences of environmental factors on leaf senescence progress and suggest that the shifts of factors affecting cold requirements under global warming may enlarge the uncertainty in predicting autumn leaf coloration dates.

A Facile Strategy to Construct Anti-Swelling, Antibacterial, and Antifogging Coatings for Protection of Medical Goggles.

During the COVID-19 (Corona Virus Disease 2019) pandemic, traditional medical goggles are not only easy to attach bacteria and viruses in long-term exposure, but easy to fogged up, which increases the risk of infection and affects productivity. Bacterial adhesion and fog can be significantly inhibited through the hydrogel coatings, owing to super hydrophilic properties. On the one hand, hydrogel coatings are easy to absorb water and swell in wet environment, resulting in reduced mechanical properties, even peeling off. On the other hand, the hydrogel coatings don't have intrinsic antibacterial properties, which still poses a potential risk of bacterial transmission. Herein, an anti-swelling and antibacterial hydrogel coating is synthesized by 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM), dimethylaminoethyl acrylate bromoethane (IL-Br), and poly(sodium-p-styrenesulfonate) (PSS). Due to the self-driven entropy reduction effect of polycation and polyanion, an ion cross-linking network is formed, which endows the hydrogel coating with excellent antiswelling performance. Moreover, because of the synergistic effect of highly hydrated surfaces and the active bactericidal effect from quaternary ammonium cations, the hydrogel coating exhibits outstanding antifouling performances. This work develops a facile strategy to fabricate anti-swelling, antifouling, and antifogging hydrogel coatings for the protection of medical goggles, and also for biomedical and marine antifouling fields.

Research on the Impact Mechanical Properties of Real-Time High-Temperature Granite and a Coupled Thermal-Mechanical Constitutive Model.

Studying the mechanical behavior of rocks under real-time high-temperature conditions is of great significance for the development of energy caverns, nuclear waste disposal projects, and tunneling engineering. In this study, a real-time high-temperature impact compression test was conducted on Sejila Mountain granite to explore the effects of temperature and external load on its mechanical properties. Based on the concepts of damage mechanics and statistics, a coupled thermal-mechanical (T-M) damage constitutive model was established, which considers the temperature effect and uses the double-shear unified strength as the yield criterion. The parameter expressions were clarified, and the accuracy and applicability of the model were verified by experimental data. The research results indicated that high temperatures had an obvious damaging and deteriorating effect on the strength of the granite, while an increase in impact velocity had an enhancing effect on the strength of the granite. The established constitutive model theoretical curve and test curve showed a high degree of agreement, indicating that the coupled T-M model can objectively represent the evolution process of damage in rocks and the physical meaning of its parameters is clear.

Hsa_circ_0008500 inhibits apoptosis of adipose-derived stem cells under high glucose through hsa-miR-1273h-5p/ELK1 axis.

Preliminary researches have confirmed that the number of apoptosis of adipose tissue-derived stem cells (ADSCs) in patients with diabetes is significantly increased, leading to a difficult healing wound. Increasing researches revealed that circular RNAs (circRNAs) can control apoptosis. However, it is still unclear whether and how circRNAs are critical for regulating ADSCs apoptosis. In this study, we utilized in vitro model in which ADSCs were cultivated with normal glucose (NG) (5.5 mM) or high glucose (HG) (25 mM) medium, respectively, and found that more apoptotic ADSCs were observed in HG medium comparing to ADSCs in NG medium. Furthermore, we found that hsa_circ_0008500 attenuated HG-mediated ADSCs apoptosis. In addition, Hsa_circ_0008500 could directly interact with hsa-miR-1273h-5p, acting as a miRNA sponge, which subsequently suppressed Ets-like protein-1(ELK1) expression, the downstream target of hsa-miR-1273h-5p. Thus, these results indicated that targeting the hsa_circ_0008500/hsa-miR-1273h-5p/ELK1 signaling pathway in ADSCs may be a potential target for repairing diabetic wounds.

A Multi-Task Multi-Stage Transitional Training Framework for Neural Chat Translation.

Neural chat translation (NCT) aims to translate a cross-lingual chat between speakers of different languages. Existing context-aware NMT models cannot achieve satisfactory performances due to the following inherent problems: 1) limited resources of annotated bilingual dialogues; 2) the neglect of modelling conversational properties; 3) training discrepancy between different stages. To address these issues, in this paper, we propose a multi-task multi-stage transitional (MMT) training framework, where an NCT model is trained using the bilingual chat translation dataset and additional monolingual dialogues. We elaborately design two auxiliary tasks, namely utterance discrimination and speaker discrimination, to introduce the modelling of dialogue coherence and speaker characteristic into the NCT model. The training process consists of three stages: 1) sentence-level pre-training on large-scale parallel corpus; 2) intermediate training with auxiliary tasks using additional monolingual dialogues; 3) context-aware fine-tuning with gradual transition. Particularly, the second stage serves as an intermediate phase that alleviates the training discrepancy between the pre-training and fine-tuning stages. Moreover, to make the stage transition smoother, we train the NCT model using a gradual transition strategy, i.e., gradually transiting from using monolingual to bilingual dialogues. Extensive experiments on two language pairs demonstrate the effectiveness and superiority of our proposed training framework.

Autoimmune gastritis with a gastric hamartomatous inverted polyp and two hyperplastic polyps: a case report.

We report an unusual case of autoimmune gastritis (AIG) complicated with a submucosal tumor (SMT) and two pedunculated polyps in a 60-year-old man. The patient was admitted for epigastric distention, heartburn, and anorexia. Endoscopy showed an SMT in the fundus, two pedunculated polyps in the body, and markedly atrophic mucosa of the body and fundus. The SMT, measuring 20 mm in diameter, was resected by endoscopic submucosal dissection and histologically diagnosed as a gastric hamartomatous inverted polyp (GHIP), which is characterized by submucosal glandular proliferation, cystic dilatation, and calcification. The gland structures consisted of foveolar cells and pseudopyloric or mucous-neck cell types. The two pedunculated polyps that were resected by endoscopic mucosal resection were histologically diagnosed as hyperplastic polyps, which are characterized by hyperplastic foveolar glands with pseudopyloric or mucous-neck glands in the inflamed stroma in the mucosa, which consisted of almost the same types of lining cells as the GHIP in the fundus. Findings may indicate the relationship between GHIP, hyperplastic polyp, and AIG. We highlight considering GHIP as a differential diagnosis for an SMT in patients with AIG.

Negative relationship between photosynthesis and late-stage canopy development and senescence over Tibetan Plateau.

Canopy greening, which is associated with significant canopy structure changes, is the most notable signal of ecosystem changes in response to anthropogenic climate change. However, our knowledge of the changing pattern of canopy development and senescence, and its endogenous and climatic drivers is still limited. Here, we used the Normalized Difference Vegetation Index (NDVI) to quantify the changes in the speed of canopy development and senescence over the Tibetan Plateau (TP) during 2000-2018, and used a solar-induced chlorophyll fluorescence dataset as a proxy for photosynthesis, in combination with climate datasets to decipher the endogenous and climatic drivers of the interannual variation in canopy changes. We found that the canopy development during the early green-up stage (April-May) is accelerating at a rate of 0.45-0.8 × 10-3  month-1  year-1 . However, this accelerating canopy development was largely offset by a decelerating canopy development during June and July (-0.61 to -0.51 × 10-3  month-1  year-1 ), leading to the peak NDVI over the TP increasing at a rate of only one fifth of that in northern temperate regions, and less than one tenth of that in the Arctic and boreal regions. During the green-down period, we observed a significant accelerating canopy senescence during October. Photosynthesis was found to be the dominant driver for canopy changes over the TP. Increasing photosynthesis stimulates canopy development during the early green-up stage. However, slower canopy development and accelerated senescence was found with larger photosynthesis in late growth stages. This negative relationship between photosynthesis and canopy development is probably linked to the source-sink balance of plants and shifts in the allocation regime. These results suggest a sink limitation for plant growth over the TP. The impact of canopy greening on the carbon cycle may be more complicated than the source-oriented paradigm used in current ecosystem models.

Climate change increases carbon allocation to leaves in early leaf green-up.

Global greening, characterized by an increase in leaf area index (LAI), implies an increase in foliar carbon (C). Whether this increase in foliar C under climate change is due to higher photosynthesis or to higher allocation of C to leaves remains unknown. Here, we explored the trends in foliar C accumulation and allocation during leaf green-up from 2000 to 2017 using satellite-derived LAI and solar-induced chlorophyll fluorescence (SIF) across the Northern Hemisphere. The accumulation of foliar C accelerated in the early green-up period due to both increased photosynthesis and higher foliar C allocation driven by climate change. In the late stage of green-up, however, we detected decreasing trends in foliar C accumulation and foliar C allocation. Such stage-dependent trends in the accumulation and allocation of foliar C are not represented in current terrestrial biosphere models. Our results highlight that a better representation of C allocation should be incorporated into models.

Hsa_circ_0000119 promoted ovarian cancer development via enhancing the methylation of CDH13 by sponging miR-142-5p.

Ovarian cancer is the leading cause of gynecological cancer-related death in women, and is difficult to treat. The aim of our study is to explore the role and action mechanism of hsa_circ_0000119 in ovarian cancer, thus to analyze whether the circular RNA is a potential target for the treatment of the disease. In this present study, our data shows that hsa_circ_0000119 and DNA methyltransferase 1 (DNMT1) was increased, while miR-142-5p was decreased in ovarian cancer. Overexpression of hsa_circ_0000119 promoted tumor growth, while silencing of hsa_circ_0000119 resulted in an opposite effects. Decreasing of hsa_circ_0000119 also notably inhibited the proliferation, migration, and invasion of the ovarian cancer cells. Moreover, the data proves that hsa_circ_0000119 negatively regulated miR-142-5p and cadherin 13 (CDH13) expression, but positively regulated DNMT1 expression. miR-142-5p could interact with hsa_circ_0000119 and DNMT1 3'-UTR. Silencing of DNMT1 could reverse the inhibition of hsa_circ_0000119 to miR-142-5p and CDH13 expression. Importantly, higher level of CDH13 promoter methylation existed in the ovarian tumors than that in matched normal tissues. DNA methyltransferase inhibitor could increase the expression of CDH13 in ovarian cancer cells. In addition, our results also prove that increasing of CDH13 or miR-142-5p effectively reversed the inhibition of hsa _circ_0000119 to the cell malignant phenotypes. Overall, our data demonstrate that hsa_circ_0000119 facilitated ovarian cancer development through increasing CDH13 expression via promoting DNMT1 expression by sponging miR-142-5p. Our data demonstrate the potential role of hsa_circ_0000119 in the treatment of ovarian cancer.

CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway.

Circular RNAs (CircRNAs) are key regulators in the development and progression of human cancers. However, the biological roles and mechanisms of circRNAs in gastric cancer (GC) remain largely unknown. Analyzing circRNA microarray dataset (GSE102686) and clinical specimens, a novel circRNA termed hsa_circ_0001627, was identified and it was highly expressed in CC cancerous tissues and cells, and was associated with poor clinical outcomes. Functionally, hsa_circ_0001627 silencing impaired the malignant progression of CC cells and the growth of CC xenografts in nude mice. Mechanistically, hsa_circ_0001627 acted as a miR-1225-5p sponge, thus indirectly regulating FNDC3B and leading to the activation of PI3K/mTOR signaling pathway. Collectively, the present study indicates that hsa_circ_0001627 regulates miR-1225-5p/FNDC3B/PI3K/mTOR axis and functions as an oncogene in CC progression, suggesting the potential therapeutic use of hsa_circ_0001627 in CC treatment.

Gradient Micropillar Array Inspired by Tree Frog for Robust Adhesion on Dry and Wet Surfaces.

The strong adhesion on dry and wet surfaces and the durability of bioinspired hierarchical fibrillar adhesives are critical for their applications. However, the critical design for the strong adhesion normally depends on fine sub-micron structures which could be damaged during repeat usage. Here, we develop a tree frog-inspired gradient composite micropillars array (GP), which not only realizes a 2.3-times dry adhesion and a 5.6-times wet adhesion as compared to the pure polydimethylsiloxane (PDMS) micropillars array (PP), but also shows excellent durability over 200 repeating cycles of attachment/detachment and self-cleaning ability. A GP consists of stiffer tips and softer roots by incorporating gradient dispersed CaCO3 nanoparticles in PDMS micropillar stalks. The modulus gradient along the micropillar height facilitates the contact formation and enhances the maximum stress during the detaching. The study here provides a new design strategy for robust adhesives for practical applications in the fields of robotics, electronics, medical engineering, etc.

Contrasting temperature effects on the velocity of early- versus late-stage vegetation green-up in the Northern Hemisphere.

Global vegetation greening has been widely confirmed in previous studies, yet the changes in the velocity of green-up in each month of green-up period (GUP) remains unclear. Here, we defined the velocity of vegetation green-up as VNDVI (the monthly increase of Normalized Difference Vegetation Index [NDVI] during GUP) and further explored its response to climate change in middle-high-latitude Northern Hemisphere. We found that in early GUP, VNDVI generally showed positive trends from 1982 to 2015, whereas in late GUP, it showed negative trends in most areas. Such contrasting trends were mainly due to a positive temperature effect on VNDVI in early GUP, but this effect turned negative in late GUP. The increase of soil moisture also in part explained the accelerated vegetation green-up, especially in the arid and semi-arid ecosystems of inland areas. Our analyses also indicate that the first month of the GUP was the key stage impacting vegetation greenness in summer. Future warming may continuously speed up the early growth of vegetation, altering the seasonal trajectory of vegetation and its feedbacks to the Earth system.

Switchable Adhesion on Curved Surfaces Mimicking the Coordination of Radial-Oriented Spatular Tips and Motion of Gecko Toes.

Bio-inspired structured adhesives have promising applications in many fields, like biomedicine, robotics, and aerospace. However, achieving robust and switchable adhesion in structured adhesives on non-planar surfaces remains highly challenging. Inspired by the gripping and rolling motions of gecko toes, a strong and switchable adhesive, which comprises a pillar array with radial-oriented spatular tips and is named as PROST, is developed. PROST possesses a robust adhesion on flat surfaces and doubles its adhesion on curved surfaces. Moreover, in situ and fast adhesion switching of PROST on flat/curved surfaces in dry and wet conditions has been realized by solvent stimulation, mimicking the bending locomotion of gecko toes. The work here provides a new strategy for designing controllable adhesion on curved substrates.

Linc01133 promotes proliferation and metastasis of human renal cell carcinoma through sponging miR-760.

Renal cell carcinoma (RCC) is one of the most frequent human tumors and has brought great threats to the health of the people around the globe. It was reported that linc01133, a long non-coding RNA (lncRNA), was involved in the pathogenesis and development of several human cancer. But the biological role of linc01133 in RCC is still not understood. The present study aimed to investigate the biological functions of linc01133 in RCC. We did some biological experiments in this study, including quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, MTT assay, wound healing assay, Transwell invasion assay and xenograft tumor assay. In this study, we found the expression levels of linc01133 markedly increased in the RCC tissues compared with the normal tissues. And we found that the over-expressing of linc01133 promoted cell proliferation, migration and invasion, the interfering of linc01133 inhibited cell proliferation, migration and invasion. Furthermore, we found that the interfering of linc01133 inhibited tumor growth in murine xenograft models. Additionally, we found that linc01133 promotes RCC cell proliferation, migration and invasion through sponging miR-760. Collectively, our work preliminarily illuminated the tumor-promoting role of linc01133 in RCC and the potential molecular mechanism. Thus, our study may provide some evidence for the treatment of RCC.

Vonoprazan non-inferior to lansoprazole in treating duodenal ulcer and eradicating Helicobacter pylori in Asian patients.

BACKGROUND AND AIM: Duodenal ulcers, especially caused by increasingly drug-resistant Helicobacter pylori, are a concern in Asia. We compared oral vonoprazan versus lansoprazole for efficacy (healing duodenal ulcers) and safety in non-Japanese Asian patients. METHODS: In this phase 3, randomized (1:1), double-blind, double-dummy, parallel-group, non-inferiority study (April 5, 2017, to July 19, 2019), patients with ≥ 1 endoscopically confirmed duodenal ulcer, at 52 hospitals (China, South Korea, and Taiwan), received vonoprazan 20 mg once daily (QD) or lansoprazole 30 mg QD for 6 weeks maximum. Patients with H. pylori received bismuth-containing quadruple therapy including vonoprazan 20 mg twice daily (BID) or lansoprazole 30 mg BID, for 2 weeks, followed by vonoprazan or lansoprazole monotherapy QD (4 weeks maximum). Endpoints were endoscopically confirmed duodenal ulcer healing (Week 4/6; primary) and H. pylori eradication (4 weeks post-treatment; secondary); non-inferiority margins were -6% and -10%, using a two-sided 95% confidence interval (CI). RESULTS: Of 533 enrolled patients, one was lost to follow-up and one withdrew (full analysis set: 531 patients [vonoprazan, n = 263; lansoprazole, n = 268]; 85.4% = H. pylori positive). Vonoprazan was non-inferior to lansoprazole for duodenal ulcer healing (96.9% vs 96.5%; difference 0.4% [95% CI -3.00, 3.79]). H. pylori eradication rates were 91.5% (vonoprazan) and 86.8% (lansoprazole; difference 4.7% [95% CI -1.28, 10.69]). Vonoprazan and lansoprazole were well tolerated, with similar safety profiles, no new safety signals; no deaths occurred. CONCLUSIONS: Vonoprazan was well tolerated and non-inferior to lansoprazole for duodenal ulcer healing and achieved H. pylori eradication above the clinically meaningful threshold (90%), in non-Japanese Asian patients.